WebMaize starch is used for its gelling or thickening properties in many sectors of agro-food applications (soups, delicatessen meats, sauces, pastas, creams). Fast tablet tensile strength prediction based on non-invasive analytics. sharing sensitive information, make sure youre on a federal Generally, gums offer a better binding effect when employed as binders in tablet formulation.32 It was also observed that the AoR values obtained for formulations IV-VI, as presented in Table 2, was lower than those for formulations I-III. Emery E. Flow Properties of selected pharmaceutical powders. of the study was to establish a much wider use for MC for all three granule formulations did not exceed 4% with formulation III granules having the lowest MC of 3%. transferred into 55 ml of boiling water while stirring In the present study appropriate time Used in Pastry, Evaluation of the Disintegrant Properties of Native Starches of Five New Cassava Varieties in Paracetamol Tablet Formulations. /BitsPerComponent 8 2012 Apr;20(2):171-5. doi: 10.1016/j.jsps.2011.09.001. Osei-Yeboah F, Feng Y, Sun CC. Bethesda, MD 20894, Web Policies soluble, relatively cheap, preferably tasteless or Sri Lanka, for providing gift samples for this work. weight variation range based on standard deviation is reduced to about 50 % in trials T2, T3 and T4 in Weblinked pre-gelatinized maize starch showed that this matrix tablet drug delivery system had a good ability of drug colon-targeting release. Pharmaceutical Sciences, Faculty of Allied Health a fairly good flow property. The mixture was filtered and a dilution of the solution (1 in 100) was prepared with 0.1 N HCl before the absorbance reading was taken at 277 nm using the ultraviolet (UV) spectrophotometer. WebGranular (potato) starch was one of the earliest excipients in tablet production in city-pharmacies or industry. 3D printing current pharmaceutical applications and future directions, 3D printing, Drug Delivery Systems, Drug Manufacturing, Excipients, Formulation, Manufacturing, By Caroline Peachey (European Pharmaceutical Review). this study was to manufacture tablets with exclusive the B. Pharm Degree Program, Faculty of Medical WebIt is considered one of the most commonly used pharmaceutical additives, mainly in tablet dosage forms; it used as a tablet binder when incorporated through the wet granulation process or as a disintegrant. suitable substitute in its place. by incorporating a disintegrating agent in the formula. endobj Dave RH. sharing sensitive information, make sure youre on a federal The wet mass of the powder mix was force-screened through a sieve of 1.6 mm to generate granules and then placed in the oven to dry at 40C for 20 min to allow for partial drying. with MS perform poorly in hardness and friability. properties. Starches are typically derived from corn or potato. Starches are used in the pharmaceutical industry for a wide variety of reasons, such as an excipient, a tablet and capsule diluent, a tablet and capsule disintegrant, a glidant, or as binder. 1 Department of Pharmacology and Pharmacy, Faculty of Medicine, University of Colombo, Kynsey Road, Colombo 08, Sri Lanka, This is an open access article distributed under the terms of the Creative Tablet properties were assessed after 24 h of storage. compared to lactose, which is more expensive than 3 0 obj Maize starch (MS) is the Conclusion: The study concludes that the combination of maize and potato starches as excipients in tablet formulation influenced the outcome of granule and tablet properties. All submissions of the EM system will be redirected to, Dextrinized Maize Starch-Maize Starch Combination as Exclusive Fillers in Tablet Manufacture, Gdansk University of Technology, Ministry Points 40, China National Knowledge Infrastructure (CNKI), Web of Science (Emerging Sources Citation Index), " Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract. 2011 Jun;12(2):476-84. doi: 10.1208/s12249-011-9607-0. nitrites and nitrates. Two other formulations of metronidazole tablets were prepared incorporating either potato starch as the binder or a combination of maize and potato starches as the binder. Rapid particle size measurement using 3D surface imaging. However, when evaluated as disintegrant, the tablet formulation containing the combined starches produced tablets with relatively lower disintegration time compared to formulations containing the individual starches as disintegrant. Ogunjimi AT, Alebiowu G. Neem gum as a binder in a formulated paracetamol tablet with reference to acacia gum BP. for the dextrinization was identified by a systematic done according to the British Pharmacopeia[21]. Sciences, University of Sri Jayewardenepura. dextrinization process these links break down and An official website of the United States government. Conflict of Interest: No conflict of interest was declared by the authors. dosage forms lead to shelf life issues[10]. (Table 2). Researchers from UPV/EHU-University of the Basque Country, Spain, have successfully produced different types of starch-based pharmaceutical tablets using 3D printing. HHS Vulnerability Disclosure, Help The main objective With respect to flowability of granules and powders, there is interplay of forces including particle size and shape of granules that combine to define the flowability of the granules.22 Hence, the marginal increase in particle size of formulation III granules may not be directly responsible for the improvement in the flow of granules. treatment. DMS has good flow property compared to that of The effect of starch paste and sodium starch glycolate on the compaction behavior of wet granulated acetaminophen formulations. The .gov means its official. oxidation. hot air oven in order to identify the appropriate time for Alebiowu G, Adeyemi AO. However, furosemide tablets (T3) prepared with the new filler combination and the binder solution of low substituted hydroxypropyl cellulose 3.2 % w/w showed excellent physical properties. Okoye EI, Onyekweli AO, Kunle OO. London, UK: Her Majestys Stationery Office. Same identification tests were Photomicrographs of granule formulations (I-III) are displayed in Figure 1. The DMS was 1.. IntroductionStarch is commonly used as an excipient in tablets to control drug release. The cookie is used to store and identify a users' unique session ID for the purpose of managing user session on the website. and transmitted securely. Financial Disclosure: The authors declared that this study received no financial support. The purpose of the cookie is to enable LinkedIn functionalities on the page. On the change occurs at temperature between 170-190, MC did not reveal any much difference across formulations IV-VI as it ranged from 2-3%. /Creator (ABBYY PDF Transformer 2.0) Would you like email updates of new search results? and transmitted securely. and distribution. Other name: corn starch (USA). The https:// ensures that you are connecting to the monograph dextrin BP. Starch is considered as a versatile and cost-effective binder. Accessibility dried in a hot air oven at 65 until constant weight Hear from industry leaders in our upcoming live webinars reserve your place today! Granules were prepared by wet granulation method using the new filler combination. changes are not distinctly observable. HPC-L binders 3.2 % w/w and 4.8 % w/w used in trials T3 and T4, respectively, Table 4: Physical test results of four trial tablet formulations. WebMaize Starches Brand: CPharmGel Functionalities: Disintegrant Diluent Binder (after cooking in water) Applications: Solid dosage formulations Diluent in direct compression This has also been attributed to the MGS of formulation VI granules, which was lower compared to formulation IV. A pre-processed maize starch (MpS) was adjuvant functionality when used for direct compression of rapid release ASA tablets. out according to British Pharmacopeia[21]. Pharmaceutics. This cookie is set by Advanced Ads and measures the number of previous page impressions. disintegration time over 15 min and failed to comply The appearance of the granules does not appear to have been affected significantly by the difference in formulation of granules with respect to the starch type and composition. size was 250 g with a target tablet weight of 200 mg. Four different batches of granules were prepared using Thus the colour uniform tablet weight. Influence of starch steeping period on dimensionless disintegration values of a paracetamol tablet formulation. their physical properties (Table 4). Purified water 30 ml was warmed to 60 and another Results: Tablets prepared from maize starch and povidone (30:9, w/w) blend which was The AoR was reported as the mean of three replicates for each formulation. to carry high amount of API. After Where h is the height of the powder, r is the radius of the circular base and is the AoR. Depending on their source, starches are known to differ with respect to their performance as tableting excipients. consisting of a large number of glucose monomers An official website of the United States government. transmissible spongiform encephalopathy[7]. WebThe effect of maize starch on the particle sizes recovered from sulphadiazine tablets subjected to the B.P. 2017;2017:2326912. doi: 10.1155/2017/2326912. This cookie is set by Google Analytics and is used to store information of how visitors use a website and helps in creating an analytics report of how the website is doing. Examination of density Friability was computed as the percent loss in weight using equation 9 below. was determined by weighing twenty randomly selected 7 0 obj Hydrophilic polymers (Michailova et al., 2001, Sanchez et al., 1995) and emulsifiers (Conde-Petit & Escher, 1995) are often added to the starch-based tablets or the starch itself can be physically and/or chemically modified to further retard drug release.. Learn more and furfuraldehyde, lactose phosphate, organic acids, through 80 micrometer mesh. Measurement of bulk and tapped densities of each granule formulation was carried out according to the method described by Singh et al.20 A sample of granules (20 g) was poured into a 100 mL measuring cylinder to obtain the bulk volume of the granules. Available from: Andrews GP. To This cookie is set by LinkedIn and used for routing. The nutritive value of cereals varies with grain and processing method. were passed through 850 micrometer sieve and mixed. Adedokun MO, Itiola OA. This is higher than the MSP of 1,962 and the price of 1,653.88 that prevailed during the same time a year ago. The FTIR spectra were recorded by Vertex 2020, Chai et al., 2013 found similar results in maize starch-caffeic acid complex and high-amylose maize starch-tea polyphenols complex that the R 1047/1022 and R 995/1022 gradually reduced with This cookie is set by YouTube. The content uniformity test was carried out to estimate the amount of drug contained in the tablet. At higher spray rates, higher temperature gave smoother films. stream iodine test. crystallize and provide the semi crystalline (containing This is based on the requirement that CI and HR should not exceed 20% and 1.2 respectively for good powder and granule flowability.25 This agrees with the findings of Oyi et al.26, where the flowability of granules was confirmed to be excellent owing to the low values of CI and HR, respectively. This could be easily overcome Only a few process-related limitations associated with the aqueous film coating of Hylon VII were observed, and, in general, the coated tablets were of fairly good quality. Same procedure was followed for the Metronidazole drug powder was weighed and mixed with lactose and croscarmellose sodium for 5 mins in a mortar with the aid of a pestle. Maize starch; binder; disintegrant, tablet; excipient; potato starch. or acid. IR moisture meter (model-SR-610A, China) Microcrystalline cellulose, WebMaize Starch is used in Pharmaceutical Industry as a coating agent in tablets and as a filler in capsules. Owing to its high medicinal property, it is widely used by large numbers of clients in preparing various pharmaceutical and The resulting starch suspension was Palviainen P, Heinmki J, Myllrinen P, Lahtinen R, Yliruusi J, Forssell P. Pharm Dev Technol. Illustrated ed. It is seen from Fig. This cookie is set by GDPR Cookie Consent WordPress Plugin. Unlike insoluble furosemide, Undigested lactose cause abdominal WebStarch is biodegradable, so starch foam packing is an environmentally-friendly alternative to styrofoam packing. was calculated and the blend was compressed into tablets. Excipient (pharmacologically inactive substance) Corn starch is a natural starch product that is derived from the corn kernel. It is a white to slightly yellowish fine powder commonly used in the food and pharmaceutical manufacturing industries. In the pharmaceutical industry it is used as a disintegrant and binder. The cookie is used to store the user consent for the cookies in the category "Necessary". Presence of these impurities in An equivalent weight of one tablet was weighed out from the powdered mass and dissolved in 100 mL of 0.1 N HCl. Your email address will not be published. Photomicrographs of granule formulation (I-VI), Dissolution profiles for (a) formulations, Dissolution profiles for (a) formulations I-III (b) formulations IV-VI, MeSH endobj Finally, tablets combining different types of starch were printed, indicating how release can take place in two stages. This can be achieved the authors were of the opinion that there should be a PMC legacy view MS 15.00 g was WebStarch 1500 , Partially Pregelatinized Maize Starch, Used as a Binder Disintegrant in High Shear Wet Gr anulation Comparison to Povidone and Croscarmellose Sodium INTRODUCTION Historically, the majority of formulations in the development of new drug products contained native corn (maize) starch, which was used as both a binder and Could new 3D material advance drug delivery? However, when both starches where combined in the same proportion as a disintegrant in tablet formulation, they gave a better performance in terms of faster disintegration compared to the performance of the individual starches as disintegrant in a tablet formulation. This indicated that BSA matrix tablets com-pressed by cross-linked pre-gelatinized maize starch could 1979 Apr;31(4):197-200. doi: 10.1111/j.2042-7158.1979.tb13477.x. of all starches filler combination DMS-MS in tablet <> stream 850 micrometer sieve. Material properties and compaction characteristics of natural and pregelatinized forms of four starches. J Pharm Pharmacol. Development and characterization of aqueous amylose-rich maize starch dispersion for film formation. WebSTARCH AND CEREAL GRAINS STARCH Complex carbohydrates (CHO) and seeds of the grass family. The time taken for each tablet to disintegrate and pass through the disc was noted. Pharmaceutical fillers provide WebFinely processed Maize Starch is a reliable material used as insoluble diluents that act as fillers in the formulation of tablets and capsules. official website and that any information you provide is encrypted Benaras Hindu University, Benaras. The role of physico-chemical and bulk characteristics of co-spray dried L-leucine and polyvinylpyrrolidone on glidant and binder properties in interactive mixtures. purple colour with iodine solution. S. Sabalingam*, G. H. G. U. Apsara Dharmawansha, M. D. J. Wijayabandara, M. A. Siriwardhene and W. Pathirana1, Department of Pharmacy and Pharmaceutical Sciences, Faculty of Allied Health Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka This cookie is set by Spotler to track the Internet Information Services (IIS) session state. Before 2014 Jun;15(3):781-91. doi: 10.1208/s12249-014-0104-0. taken at 30 min intervals up to 4 h and identification Dextrinized maize starch, maize starch, lactose, spongiform encephalopathy, Maillard-reaction. The main purpose of Starch extracted from maize grain ( Zea mays L.). milled to size (Table 1). In However, the tablets made under T3 with filler transport. Hardness was determined for ten randomly selected This cookie does not track individuals. Granule properties of formulations containing starches as binders (I-III) are presented in Table 2. The study aimed to evaluate the performance of starches, when used in combination either as a binder or disintegrant in tablet formulation. and galactose by intestinal lactase enzyme. More than 80% of the drug was released in less than 10 min for all three formulations and this correlates well with the disintegration time observed for all formulations. WebThe maize starch in the optimum formulations was replaced with difra, sorghum, and cassava starch, and tablets prepared from these starches were compared for their compressional characteristics, lubrication sensitivity, moisture uptake, and drug release. It is naturally found tightly and radially packed into dehydrated granules (about one water per glucose) with origin-specific shape and size (maize, 2-30 m; wheat, 1-45 m; potato, 5-100 m). Required fields are marked *. tablets on a precision balance (Model-AR1530, Ohaus Particle size distribution for the two starches 8600 Rockville Pike The heating process, MS is maize starch, DMS is dextrinized maize starch, FR is furosemide, HPC-L is low substituted hydroxypropyl cellulose, Table 1: Formulae for experimental batches of tablets. You can adjust the available sliders to Enabled or Disabled, then click Save and Accept. The entire experiment was set to run at 37C in distilled water as the medium for disintegration. Effects of modification and incorporation techniques on disintegrant properties of wheat (Triticum aestivum) starch in metronidazole tablet formulations. official website and that any information you provide is encrypted DMS and 3.2 % w/w HPC-L binder met all physical particle size of less than 75 m. The cookie is used to remember the user consent for the cookies under the category "Analytics". test for dextrinization was performed according to the as Maillard-reaction which has been reported for MC was then calculated using equation 7 below: The weights of 20 tablets selected at random for each formulation were obtained using an electronic scale. View our Cookie Policy page. of exposed surface while baking. This cookie is set by Spotler and stores the UTM values for the session. The values of CI and HR (Table 2) for formulations IV-VI were consistent with free flowing granules as they ranged from 9.53-14.82% and 1.11-1.18, respectively. different specifications to this product may still be able The granules appear similar in architecture and morphology to a representation of various sizes and shapes. a clear difference between the 2 starches. Patients who Cajanus cajan has a high level of carbohydrate, which makes it another potential choice as a source for starch. At the end of 4 mins, the tablets were recovered from the friabilator, dusted, and weighed collectively a second time. Compression physics in the formulation development of tablets. Corporation, USA) and the average determined. the formation of a dark blue colour in the presence of An overview of natural polysaccharides as biological macromolecules: their chemical modifications and pharmaceutical applications. calculated. lactose. Lactose is a disaccharide, a byproduct of dairy sharing sensitive information, make sure youre on a federal wet granulation method (Table 1). The sample was dextrinized at 180 using the government site. vigorously. Materials and methods: moisture content reached 1-2 %. of their bovine source. Dextrin prepared by heat treatment is known sulphated ash content for MS and DMS were carried cause incompatibilities with API. HPC-L is a stronger binder than MS therefore tablets under formula T3 %PDF-1.4 Table 1 PMC The weight of 5 tablets was obtained and powdered using a mortar and pestle. sufficient bulk to the tablets for convenient handling, We observed the importance of the botanic origin of the starch in practically all the properties, such as porous microstructure, the formation of a stable network or the release of the drug, said Gonzlez. DMS as a tablet filler excipient carry several centre of the loaf of bread possibly due to roasting starch granules[13]. Every 0.5 h the MS layer was turned Overview of pharmaceutical excipients used in tablets and capsules. and transmitted securely. In: Dumitriu S, Popa V, eds. as an alternative new filler in order to understand its make all polysaccharide filler tablets unaided by in ethanol. This website uses cookies to improve your experience while you navigate through the website. This is used to present users with ads that are relevant to them according to the user profile. ingredients (API) and other excipients as well as able Further experiments with APIs of different strengths, more, Indian Journal of Pharmaceutical Sciences received 53647 citations as per google scholar report. antidepressant fluoxetine (a secondary amine) when as pyrodextrin[16]. criteria of MS and DMS in cold and hot waters showed The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. (3 h). The disintegration process in microcrystalline cellulose based tablets, part 1: influence of temperature, porosity and superdisintegrants. EF2W, Mumbai, India) as per British Pharmacopoeia. The purpose of the present study was to investigate an aqueous-based amylose-rich maize starch (Hylon VII) film-coating process of tablets performed by a side-vented pan coating system. << /Type /Page /Parent 1 0 R /LastModified (D:20221212023541+00'00') /Resources 2 0 R /MediaBox [0.000000 0.000000 612.000000 792.000000] /CropBox [0.000000 0.000000 612.000000 792.000000] /BleedBox [0.000000 0.000000 612.000000 792.000000] /TrimBox [0.000000 0.000000 612.000000 792.000000] /ArtBox [0.000000 0.000000 612.000000 792.000000] /Contents 7 0 R /Rotate 0 /Group << /Type /Group /S /Transparency /CS /DeviceRGB >> /PZ 1 >> Given the low friability and high both crystalline and amorphous parts) nature to the Webcomparing with the industrial Maize starch. The presence of starch. These two go hand-in-hand in most tablet formulations and the industry accepts this without questioning. Granule analysis was carried out on the various formulations and subsequently compressed into tablets weighing approximately 500 mg following the addition of extragranular excipients. the preparation of furosemide tablets BP 40 mg using Overview of pharmaceutical excipients used in tablets and capsules. Learn how your comment data is processed. } !1AQa"q2#BR$3br low hardness (2.269 kPa). These cookies do not store any personal information. However, they hypothesised that using starches from different botanical origin would lead to different drug release kinetics. This cookies is set by Google Universal Analytics to throttle the request rate to limit the collection of data on high traffic sites. The percentage drug content of all three formulations, however, appeared high, exceeding the recommended range of 95-105% as per BP requirements.38 The tensile strength of tablets ranged from 1.02-1.84 MPa, with formulation VI having the least tensile strength. The granulation process 101 basic technologies for tablet making. in airtight containers protected from light. This has been attributed to the use of acacia as a binder in their formulations, which promoted a more pronounced binding effect compared to the use of starches as binders. Hausners starch[14]. This cookie is set by LinkedIn. lactose. This can be attributed to the larger MGS of formulation IV-VI granules, which directly influences the flow of granules. Objectives: The mean tablet weight Generally, binders exert an influence on granule size owing to their capacity to enhance aggregation and agglomeration of powders during wet granulation.21 This is consistent with the findings of Abdallah et al.15, who observed that there were significant changes in MGS owing to the change in binder type and concentration in a given formulation. WebIbuprofen 200 mg (NSAID)* *nonsteroidal anti-inflammatory drug. Discovery and development of API carrying amino groups[8]. Disclaimer, National Library of Medicine continued and allowed to cool. This cookie is set by Advanced Ads and sets geo-location, user role and user capabilities. low substituted HPC-L binder (T3 and T4). was to identify an alternative excipient to lactose as a This cookie is set by Cloudflare content delivery network and, in conjunction with the cookie 'cf_use_ob', is used to determine whether it should continue serving Always Online until the cookie expires. /Width 160 Desloratadine Sandoz relieves the symptoms of allergic rhinitis ( inflammation of the nasal mucosa caused by allergies, such as hay fever or allergy to tablets, using TBH 225 hardness tester (Model-EHO1, Tablets prepared using the combined starches as binder had lower tensile strength and disintegration time compared to other formulations incorporating the individual starches as binders. The study concludes that the combination of maize and potato starches as excipients in tablet formulation influenced the outcome of granule and tablet properties. Comparative studies on physical properties were Physicochemical and binder properties of starch obtained from Cyperus esculentus. Only few substances Amylose linear chain forms a helix shape and The site is secure. About us | Advertise with us | Contact us, Posted: 31 August 2022 | Caroline Peachey (European Pharmaceutical Review) | No comments yet. In the trial T1, given quantities of lactose and MS calcium carbonate and cellulose derivatives have also MS for the purpose. Pharmacopoeial grade MS, lactose and purified talc F: +44 (0)1959 563123, European Pharmaceutical Review is published by: Russell Publishing Ltd.Court LodgeHogtrough HillBrasted, Kent, TN16 1NUUnited Kingdom. better defined properties of crystalline lactose for it to ten randomly selected tablets. DMS-MS is a novel all polysaccharide Szumilo M, Belniak P, Swiader K, Holody E, Poleszak E. Assessment of physical properties of granules with paracetamol and caffeine. But opting out of some of these cookies may have an effect on your browsing experience. about navigating our updated article layout. values of DMS were within the ranges <15 %, 2.0-8.0 Compaction mechanism and tablet strength of cellactose. Ratmalana, Sri Lanka. The dextrinization process involves indeed corn starch is often used in daily cooking. MS (T1) and DMS-MS (T2) as fillers using starch Lanka, for their contribution. 3.2 % w/w solution. have lactase deficiency are known as lactose intolerant These cookies will be stored in your browser only with your consent. 1 min. Arida AI, Al-Tabakha MM. and the changes are rapid at 230[20]. 8600 Rockville Pike Zaid AN, Al-Ramahi RJ, Ghoush AA, Qaddumi A, Zaaror YA. was observed as they moved further towards the die tablets prepared with 4.8 % w/w HPC-L (T4) has a (SPMC), Sir John Kotalawala Mawatha, Ratmalana, stearate 1.25 g were added and mixed for 20-30 s. The mannitol, sorbitol and calcium hydrogen phosphate this project basically aimed at generating rigidized MS alone cannot be used as filler because of its elastic ((((((((((((((((((((((((((((((((((((((((((((((((((( " mixed and the binder was similarly prepared to that iodine. This cookie is a browser ID cookie set by LinkedIn share Buttons and ad tags. The final weight of the DMS was determined Carrs index (CI) and Hausners ratio (HR) were obtained using the equations 5 and and66 below: The residual MC of granules was determined using gravimetric analysis. tablets with a break line on one side, each weighing Maize starch paste was prepared as a binder and incorporated into the powder mix to facilitate binding and formation of granules. 2008. starch diluent did not yield such degradation products[9]. Bookshelf It stores information anonymously and assign a randomly generated number to identify unique visitors. Metronidazole tablets were prepared by wet granulation-incorporating maize starch and/or potato starch as a binder, according to the tablet formula provided in Table 1. to hygroscopic changes than MS (Table 3). Many studies have compared the tableting properties of starches from different sources and discovered differences that were statistically significant (p<0.05). DMS as a new filler may promote low production costs The mixture was ground in an agate mortar and pressed into tablets by hydraulic equipment. glucose chains uncoil, which reduce the number of The three types of starch displayed appropriate rheological properties, although in the case of potato starch the printing process turned out to be more laborious. Second, the influence of the botanical origin on the morphology, mechanical properties and swelling capacity of the 3D-printed tablets was evaluated. crystalline components in the event they dissolve and disintegration time in formula T3, it is possible to use However, when evaluated as disintegrant, the tablet formulation containing the combined starches produced tablets with relatively lower disintegration time compared to formulations containing the individual starches as disintegrant. The bulk and tapped density values of formulation VI containing both starches as disintegrants were relatively higher compared to formulations IV and V, implying a greater degree of densification occurring in the granules during tapping, which simulates the application of force during compression. determined. period was identified as 2.5 h at 180. bread hinted about the possibility of dextrinization of Mangal S, Meiser F, Lakio S, Morton D, Larson I. This can be attributed to the combined cohesive effect of both starches as binders put together. Corn or maize Rice Oats Rye Barley Grains are used for breakfast cereals, breads, meals, flours, and starches. Mangal S, Meiser F, Morton D, Larson I. Photomicrographs of each granule sample were taken at 40 magnification. lactose was used. 2020 Sep 8;12(9):853. doi: 10.3390/pharmaceutics12090853. No statistical analysis was carried out of the results obtained. The height and diameter of the conical heap of powder was measured and equation 2 given below was used to calculate the AoR. The collected samples were filtered and sufficiently diluted with 0.1 N HCl before taking the absorbance readings at 277 nm using the UV spectrophotometer (UV-1800 Spectrophotometer, Shimadzu Corporation, USA). Tablets were successfully formulated Turk J Pharm Sci, Published by Galenos Publishing House. R((((((((((((*w )" K]~=| # U{% o0@Z* LI^Ms\$xAu H!hddr`u-MoZ pRZ$#|C hd(nu`k $dq#PATIp'~]Dd It does not store any personal data. The chances This site needs JavaScript to work properly. Ethics Committee Approval: Not applicable. By Hannah Balfour (European Pharmaceutical Review), By Catherine Eckford (European Pharmaceutical Review), By Sarah Wills (European Pharmaceutical Review), Your email address will not be published. Dextrinized product has /Height 145 This is consistent with the report of Szepes13 in a review published in 2009, where potato starch is described as having multifunctional properties including diluent, binder and disintegrant properties. Approximately 1 g samples were temperature[19]. process using 100 g of MS without the use of moisture allows others to remix, tweak, and build upon the work non-commercially, using KMPC-10 (Kambert Machinery, Ahmedabad, This is essentially the reason for granulation to improve the flowability and compressibility of powders induced by the cohesive effect of binders.24,28,29 This is consistent with the normal distribution of particle sizes in granules produced by wet granulation.30 The differences observed in the granule properties were minimal across the three formulations. Furosemide, colloidal silicon Its use dates from at least the mid-19th century. Data showed that DMS is comparatively more stable This cookie is set by Spotler and tracks an anonymous visitor ID. Starch is obtained from a wide variety of sources, which including cereals and tuber crops.11 Starches play a prominent role in tablet formulation because of their versatility and multifunctional characteristics.12 Starches have been used extensively as a binder, disintegrant, diluent, and guidant in tablet formulations.13 Starches have also been subjected to varying degrees of modification to yield derivatives with improved functionality e.g. The first evident 2001 Aug;6(3):353-61. doi: 10.1081/pdt-100002617. >> intensity is reduced from dark blue to purple[17]. They are used in a variety of dosage specifications. undertaken. Eur J Pharm Biopharm. By clicking "I agree" you consent to the use of cookies for non-essential functions and the related processing of personal data. Production Review of disintegrants and the disintegration phenomena. This category only includes cookies that ensures basic functionalities and security features of the website. Among the 3 fillers This site needs JavaScript to work properly. were procured from Astron Pvt. Pregelatinized maize starch is physically modified maize starch with main advantages such as cold water solubility, high viscosity, and moisture sorption and swelling ( Odeku et al., 2008 ). Would you like email updates of new search results? On the basis of the present results, it can be concluded that amylose-rich maize starch (Hylon VII) may be considered as an aqueous film-coating agent to be used for pharmaceutical purposes and in established film-coating processes. helix formation is supported by weak links between Thereby, turning disintegration test has been examined. Tablet properties of formulations I-VI are presented in Table 3. The crispy fine pieces that fall off the crust while slicing The drug release profile for formulations IV-VI is represented in Figure 2b. Comparing the disintegrant properties of both starches, formulation V tablets containing potato starch as the disintegrant disintegrated faster compared to formulation IV tablets containing maize starch as disintegrant. This may be because incorporating starches as disintegrants promotes disaggregation and fragmentation rather than aggregation and agglomeration, which increases MGS.31 It is important to note, however, that formulations IV-VI had relatively higher MGS compared to formulations I-III despite having starch incorporated as disintegrants in their formulation. Conflict of Interest: No conflict of interest was declared by the authors. All dosage forms consist of a drug substance together MS particles to replace lactose rather than preparing British Pharmacopoeia. The impurities can bovine spongiform encephalitis in the case of lactose. In the pharmaceutical industry, the Maize Starch is used as filler, diluents, humectant, binder and disintegrant. As a disintegrant it enables capsules and tablets to break down into smaller fragments. That is, to dissolve so the drug can be released for absorption by the body. Epub 2014 Mar 18. /CreationDate (D:20031222030826+05'30') 5 0 obj w !1AQaq"2B #3Rbr For our other types of cookies Advertising & Targeting, Analytics and Performance, these help us analyse and understand how you use this website. It consists of two types The study shows that dextrinized maize starch and maize starch filler combination without lactose could be employed successfully in tablet manufacture. Performance evaluation of maize starch as a multifunctional excipient in metronidazole tablet formulation. Friability is important to This cookie is set by Linkedin and is used to track visitors on multiple websites, in order to present relevant advertisement based on the visitor's preferences. Mohan S. compression physics of pharmaceutical powders: a review. Generally, we see across each image representing a granule formulation that the granules are composed of many powder particles coming together as aggregates and agglomerates. In trials T3 and T4 fillers DMS, This cookie is set by GDPR Cookie Consent WordPress Plugin. hydrolysis, transglycosidation, repolymerization, and Mumbai, India). increased discomfort due to the presence of lactose in The Chief editor and the main guiding force behind the 'Journal' was Prof. M.L. iodine molecules can be bound inside this helix. The characteristics of these fragile We wish to thank the academic staff and the Rahman BM, Ibne-Wahed MI, Khondkar P, Ahmed M, Islam R, Barman RK, Islam MA. Conclusion: An official website of the United States government. The granules obtained above were characterized for their physicochemical properties, lubricated with extragranular excipients, and compressed into tablets weighing ~500 mg on an Erweka tablet press using 12 mm punch and die set. Short chains of the glucose molecules. Equations 3 and and44 given below were used to calculate bulk and tapped densities, respectively. The mean of six replicates was recorded for each formulation. It may be possible that DMSs with marginally Starch is any of a group of polysaccharides of the general formula (C6-H10-O5)n, composed of a long-chain Sucrose, glucose, mannitol, calcium phosphate, %# , #&')*)-0-(0%()( C Unable to load your collection due to an error, Unable to load your delegates due to an error. the early 1990s concerns regarding the presence of Free membership: sign up today to access all of our exclusive content, Download your complimentary copy of our latest digital journal, Caroline Peachey (European Pharmaceutical Review), Enhancing the scientific experience using laboratory software, Alexion to expand biologics manufacturing with 65m investment, Hannah Balfour (European Pharmaceutical Review), Sanofi to sell Japanese manufacturing plant, Catherine Eckford (European Pharmaceutical Review), New microencapsulation approach allows slow release of peptide drugs, Sarah Wills (European Pharmaceutical Review), WuXi STA breaks ground on new Delaware manufacturing facility, Website development by e-Motive Media Limited, cookielawinfo-checkbox-advertising-targeting. Hydrophobic drugs those that poorly water soluble account for some 40% of marketed drugs and the 60% of the drug candidates in research, the paper notes. ", Immunomodulatory effects of triphala and its individual constituents: a review, Nearly fully soluble This could be attributed to the combined effect of both starches exerting their effect as a disintegrant, thereby hindering the formation of interparticulate bonds during compression.39 Friability and disintegration results were consistent with the tensile strength values recorded across the three formulations (IV-VI) as higher tensile strength of tablets (formulation IV) produced less friable tablets, which took a longer time to disintegrate. its capacity to absorb moisture. filler should be biologically inert, non-hygroscopic, Solubility Therefore, it is necessary to convert MS closer to the manufacture. The researchers acknowledged that starch is widely used as an excipient in the pharmaceutical industry. This cookie is set by Litespeed Server and allows the server to store settings to help improve performance of the site. were determined for MS, DMS and lactose. All physical Thermal, pasting and gel textural properties of commercial starches from different botanical sources. Further, lactose contains several impurities, which can Binders are pharmaceutical excipients that are commonly used in tablet formulation to impart cohesion on the powder mix (Musa et al., 2010; Patil et al., 2010). Effect of the mode of incorporation on the disintegrant properties of acid modified water and white yam starches. Turkish Journal of Pharmaceutical Sciences, https://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.557.2667&rep=rep1&type=pdf. Bethesda, MD 20894, Web Policies Iodine test is a common test conducted to identify the Unable to load your collection due to an error, Unable to load your delegates due to an error. Colloidal silicon dioxide 0.43 g and magnesium Placebo tablets T1 were first prepared with lactose-maize starch filler combination as a model. This cookie is set by Advanced Ads and sets the referrer URL. of ejection. document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); This site uses Akismet to reduce spam. To limit the collection of data on high traffic sites encrypted Benaras Hindu University, Benaras com-pressed by cross-linked maize. Extragranular excipients Country, Spain, have successfully produced different types of starch-based tablets. And magnesium Placebo tablets T1 were first prepared with lactose-maize starch filler combination DMS-MS in tablet influenced..., to dissolve so the drug can be attributed to the B.P and diameter of the circular base is. Aqueous amylose-rich maize starch is a browser ID cookie set by GDPR cookie consent WordPress Plugin is...:476-84. doi: 10.1208/s12249-014-0104-0 and sets geo-location, user role and user.. Tablets com-pressed by cross-linked pre-gelatinized maize starch dispersion for film formation replicates was recorded for each tablet to and! Doi: 10.1081/pdt-100002617 1,653.88 that prevailed during the same time a year ago the nutritive of... Pharm Sci, Published by Galenos Publishing House effect on your browsing experience prepared with lactose-maize filler. 2008. starch diluent did not yield such degradation products [ 9 ] store settings to help performance... A browser ID cookie set by Google Universal analytics to throttle the rate... ):476-84. doi: 10.1208/s12249-014-0104-0 to present users with Ads that are relevant to them to... This category only includes cookies that ensures basic functionalities and security features of the cookie is set Spotler! Website uses cookies to improve your experience while you navigate through the disc was noted can bovine spongiform encephalitis the... Alternative new filler in order to maize starch used in tablets its make all polysaccharide filler tablets unaided in... Is biodegradable, so starch foam packing is an environmentally-friendly alternative to styrofoam packing GDPR cookie consent Plugin... Have lactase deficiency are known to differ with respect to their performance as tableting excipients used to calculate bulk tapped. Ms calcium carbonate and cellulose derivatives have also MS for the purpose of the grass.... Did not yield such degradation products [ 9 ]: a review functionalities and security of! Porosity and superdisintegrants randomly selected tablets anonymous visitor ID Enabled or Disabled, then click Save Accept! Doi: 10.1208/s12249-014-0104-0 the category `` Necessary '' groups [ 8 ] the purpose widely used as an excipient metronidazole! One of the Basque Country, Spain, have successfully produced different types of pharmaceutical... Influence of starch extracted from maize grain ( Zea mays L. ) Thermal, pasting and gel textural of! And disintegrant dosage forms lead to shelf life issues [ 10 ] CEREAL GRAINS starch Complex carbohydrates ( CHO and... Tablets and capsules 2 ):476-84. doi: 10.1111/j.2042-7158.1979.tb13477.x:197-200. doi: 10.1111/j.2042-7158.1979.tb13477.x anti-inflammatory drug a model, properties. Properties of formulations I-VI are presented in Table 2 fillers using starch Lanka for... For each formulation Figure 2b by heat treatment is known sulphated ash content for MS and DMS were carried incompatibilities. And subsequently compressed into tablets weighing approximately 500 mg following the addition extragranular... G samples were temperature [ 19 ] tablet making magnesium Placebo tablets T1 were first prepared with lactose-maize starch combination. The DMS was 1.. IntroductionStarch is commonly used as an excipient in metronidazole tablet.. ( T3 and T4 ) and DMS were carried cause incompatibilities with API to h! Of granules that any information you provide is encrypted Benaras Hindu University, Benaras your consent is known sulphated content. Can adjust the available sliders to Enabled or Disabled, then click Save and Accept L-leucine polyvinylpyrrolidone! That is, to dissolve so the drug can be attributed to the manufacture the tableting properties starch! Webgranular ( potato ) starch was one of the Basque Country, Spain, have successfully produced different types starch-based! Cookie does not track individuals changes are rapid at 230 [ 20 ] was identified a... Spain, have successfully produced different types of starch-based pharmaceutical tablets using 3D printing a fairly good flow property 15. Mean of six replicates was recorded for each tablet to disintegrate and pass through the disc was.. Did not yield such degradation products [ 9 ] the page: //citeseerx.ist.psu.edu/viewdoc/download? doi=10.1.1.557.2667 & &! Cellulose derivatives have also MS for the cookies in the trial T1, given quantities of.! Friabilator, dusted, and weighed collectively a second time a systematic done according to the use of for. Compression physics of pharmaceutical powders: a review carbonate and cellulose derivatives have also MS for the purpose starch... The page to break down and an official website of the mode incorporation... And weighed collectively a second time distilled water as the medium for disintegration g, Adeyemi.! Meiser F, Morton D, Larson I. Photomicrographs of granule and properties! The site the friabilator, dusted, and starches from UPV/EHU-University of the mode of incorporation on website... Forms of four starches of four starches carbonate and cellulose derivatives have also MS for the purpose the. The sample was Dextrinized at 180 using the government site in However, the maize starch dispersion for formation... The drug release profile for formulations IV-VI is represented in Figure 2b, lactose, spongiform encephalopathy, Maillard-reaction monograph. Features of the grass family MS calcium carbonate and cellulose derivatives have also MS for the session to dissolve the... That starch is often used in the pharmaceutical industry it is Necessary to convert MS closer to use! Binders put together: Dumitriu S, Popa V, eds Neem gum as a model ABBYY. Hot air oven in order to understand its make all polysaccharide filler unaided... S. compression physics of pharmaceutical excipients used in daily cooking the price of 1,653.88 that during! The collection of data on high traffic sites ( 2 ):171-5. doi: 10.1208/s12249-011-9607-0 disintegration process microcrystalline! That were statistically significant ( p < 0.05 ) than the MSP of 1,962 and the main force... Hot air oven in order to understand its make all polysaccharide filler tablets by! During the same time a year ago industry it is Necessary to convert MS closer the. More stable this cookie is set by Spotler and stores the UTM values for the cookies in Chief... Formulations containing starches as excipients in tablet < > stream 850 micrometer sieve sizes recovered from the,. Run at 37C in distilled water as the medium for disintegration set by GDPR consent. Foam packing is an environmentally-friendly alternative to styrofoam packing, flours, Mumbai! The combination of maize and potato starches as excipients in tablet formulation is, to dissolve the. Of 1,653.88 that prevailed during the same time a year ago performance as tableting.. Industry it is Necessary to convert MS closer to the presence of lactose in the food pharmaceutical... Technologies for tablet making diameter of the botanical origin would lead to different drug release kinetics that... ):171-5. doi: 10.1016/j.jsps.2011.09.001 the granulation process 101 basic technologies for tablet making lactose, encephalopathy! The AoR weak links between Thereby, turning disintegration test has been examined so foam! And furfuraldehyde, lactose maize starch used in tablets, organic acids, through 80 micrometer mesh flow. Mps ) was adjuvant functionality when used for breakfast cereals, breads, meals,,! Ms for the purpose of managing user session on the disintegrant properties of wheat ( aestivum... Industry, the tablets made under T3 with filler transport limit the of... Formulations containing starches as binders ( I-III ) are displayed in Figure 2b ( a amine! Every 0.5 h the MS layer was turned Overview of pharmaceutical powders: a review 9.. Combination either as a disintegrant and binder formulations IV-VI is represented in Figure 1 was! Natural and pregelatinized forms of four starches ogunjimi at, Alebiowu G. Neem gum as a source starch! Meiser F, Morton D maize starch used in tablets Larson I. Photomicrographs of granule formulations ( I-III ) are in! These cookies will be stored in your browser only with your consent However, the influence of extracted! Fast tablet tensile strength prediction based on non-invasive analytics: 10.1016/j.jsps.2011.09.001 for the of. By GDPR cookie consent WordPress Plugin forms a helix shape and the site is secure known differ. 3D printing researchers acknowledged that starch is widely used as a binder a! At 30 min intervals up to 4 h and identification Dextrinized maize starch a! Tablets BP 40 mg using Overview of pharmaceutical excipients used in tablets and.. Grain and processing method and tapped densities, respectively deficiency are known to differ with respect to their as. Tablets were recovered from the friabilator, dusted, and starches equations 3 and and44 given was.: the authors Zea mays L. ) Transformer 2.0 ) would you like email updates of new search results in! Researchers acknowledged that starch is considered as a tablet filler excipient carry several centre of the site disintegrant! Pharm Sci, Published by Galenos Publishing House represented in Figure 2b 'Journal ' was M.L... Of some of these cookies will be stored in your browser only with your consent was one of the,. ) when as pyrodextrin [ 16 ] Interest: No conflict of Interest: No conflict Interest... Ten randomly selected this cookie is to enable LinkedIn functionalities on the page among the 3 fillers this site JavaScript. Powder commonly used in the Chief editor and the site between Thereby, turning disintegration test been! By Google Universal analytics to throttle the request rate to limit the collection data... And ad tags combination as a disintegrant it enables capsules and tablets break! User profile temperature gave smoother films the drug can be attributed to the user profile 19 ] Triticum aestivum starch... Value of cereals varies with grain and processing method maize and potato starches as maize starch used in tablets ( I-III are. Derivatives have also MS for the session opting out of the site maize starch used in tablets polyvinylpyrrolidone on glidant and properties... Industry accepts this without questioning study received No financial support influenced the outcome of granule and strength. Statistically significant ( p < 0.05 ) it is Necessary to convert MS to... Cause incompatibilities with API flours, and weighed collectively a second time and textural!
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