The fine skin flaking that is often seen can be gently exfoliated with a washcloth. The threonine abbreviation is Thr, and its one letter code is T. The proper threonine pronunciation is three-uh-need. The threonine formula is C4H9NO3, and it contains an a-amino group, a carboxyl group and a side chain containing a hydroxyl group. 2a07: Crystal Structure of Foxp2 bound Specifically to DNA. [39][41], Tretinoin has been explored as a treatment for hair loss, potentially as a way to increase the ability of minoxidil to penetrate the scalp, but the evidence is weak and contradictory. (chemistry) The chemical element boron. [5] Using a combination of bioinformatics and RNA analyses, they discovered that the gene codes for a novel protein belonging to the forkhead-box (FOX) group of transcription factors. Ixekizumab, sold under the brand name Taltz, is an injectable medication for the treatment of autoimmune diseases.Chemically, it is a form of a humanized monoclonal antibody. The researchers suggested that the gene is more active in "the more communicative sex". [15], Study M14-387 (NCT02287233) was a non-randomized, open-label trial of venetoclax in combination with low-dose cytarabine (n=61) in newly diagnosed participants with AML, including participants with previous exposure to a hypomethylating agent for an antecedent hematologic disorder. [8] It also failed to demonstrate efficacy in treating acute myeloid leukemia in a phase II study. It's more than just genes", "FoxP2 regulation during undirected singing in adult songbirds", "Behavior-linked FoxP2 regulation enables zebra finch vocal learning", "For whom the bird sings: context-dependent gene expression", "Praxic and nonverbal cognitive deficits in a large family with a genetically transmitted speech and language disorder", "Functional genetic analysis of mutations implicated in a human speech and language disorder", "Absence of a paternally inherited FOXP2 gene in developmental verbal dyspraxia", Gene information at Genetic Home Reference, Max Planck Institute for Psycholinguistics, Revisiting FOXP2 and the origins of language, transcription factor/coregulator deficiencies, https://en.wikipedia.org/w/index.php?title=FOXP2&oldid=1116897496, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 18 October 2022, at 22:23. ", "The protective activity of tea catechins against experimental infection by Vibrio cholerae O1", "Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions", "High-throughput analysis of promoter occupancy reveals direct neural targets of FOXP2, a gene mutated in speech and language disorders", "A functional genetic link between distinct developmental language disorders", "The human language-associated gene SRPX2 regulates synapse formation and vocalization in mice", "Why can't chimps talk? [5], Venetoclax attaches to a protein called Bcl-2. They can receive blood from type B or type O, but cannot receive blood from AB or A. [6][7][8] For acne, it is applied to the skin as a cream, gel or ointment. In biochemistry, a ligase is an enzyme that can catalyze the joining of two large molecules by forming a new chemical bond.This is typically via hydrolysis of a small pendant chemical group on one of the larger molecules or the enzyme catalyzing the linking together of two compounds, e.g., enzymes that catalyze joining of C-O, C-S, C-N, etc. The substance acts as a phosphoinositide 3-kinase inhibitor; more specifically, it blocks P110, the delta isoform of the enzyme phosphoinositide 3-kinase. In: Cosmetic Formulation of Skin Care Products, Taylor and Francis Group, New York 2006. p.273. [41][42], DNA sampling from Homo neanderthalensis bones indicates that their FOXP2 gene is a little different though largely similar to those of Homo sapiens (i.e. Amides are pervasive in nature and technology. The associated jaundice is usually self-limiting and very rarely fatal.[2][3]. Etoposide, sold under the brand name Vepesid among others, is a chemotherapy medication used for the treatments of a number of types of cancer including testicular cancer, lung cancer, lymphoma, leukemia, neuroblastoma, and ovarian cancer. It is not only because of the positive charge on the nitrogen, but also because of the negative charge on the oxygen gained through resonance. The most common side effects include nausea (feeling sick), thrombocytopenia (low blood platelet counts), tiredness and weakness, anemia (low red blood cell counts), The name isotretinoin is the same root tretinoin plus the prefix iso-. The human allele of the FOXP2 gene was transferred into the mouse embryos through homologous recombination to create humanized FOXP2 mice. [12], The antibody has affinity to the homodimer IL-17A and the heterodimer IL-17A/F, but not to other members of the interleukin 17 family. Lurbinectedin, sold under the brand name Zepzelca, is a medication used for the treatment of small cell lung cancer.. [5][6] Studies of the gene in mice and songbirds indicate that it is necessary for vocal imitation and the related motor learning. [6], Like other antibodies, ixekizumab is probably degraded by proteolysis. Other common side effects included injection site pain (1317% versus 3%), oropharyngeal pain (1%) and nausea (12%). The use of clavulanic acid with penicillins has been associated with an increased incidence of cholestatic jaundice and acute hepatitis during therapy or shortly after. [23], In a mouse FOXP2 gene knockouts, loss of both copies of the gene causes severe motor impairment related to cerebellar abnormalities and lack of ultrasonic vocalisations normally elicited when pups are removed from their mothers. Arsenic trioxide, sold under the brand name Trisenox among others, is an inorganic compound and medication. [4][5], The most common side effects are low levels of neutrophils (a type of white blood cell), diarrhea, nausea, anemia (low red blood cell counts), nose and throat infection and tiredness. [4] Venetoclax is excreted from the body via the fecal route. [4] The safety and efficacy of ixekizumab were established in three randomized, placebo-controlled clinical trials with a total of 3,866 participants with plaque psoriasis who were candidates for systemic or phototherapy therapy. [13], The application for venetoclax in combination with rituximab was granted priority review along with a breakthrough therapy designation. Amides are prevalent throughout the natural and engineered world. The specific mechanism of how this enzyme works is not fully understood, but this enzyme regulates 3 steps in the overall synthesis of clavulanic acid. It is taken by mouth. [10] Trial participants took venetoclax orally every day, beginning with 20mg and increasing over a five-week period to 400mg.[10] Results showed that 80 percent of trial participants experienced a complete or partial remission of their cancer. The FOXP2 gene has been implicated in several cognitive functions including; general brain development, language, and synaptic plasticity. [12] However, other genes are necessary for human language development, and a 2018 analysis confirmed that there was no evidence of recent positive evolutionary selection of FOXP2 in humans. These areas are commonly known as areas of language function. Lurbinectedin, sold under the brand name Zepzelca, is a medication used for the treatment of small cell lung cancer.. Only a few targeted genes have been identified, however researchers believe that there could be up to hundreds of other genes targeted by the FOXP2 gene. Etoposide, sold under the brand name Vepesid among others, is a chemotherapy medication used for the treatments of a number of types of cancer including testicular cancer, lung cancer, lymphoma, leukemia, neuroblastoma, and ovarian cancer. [34] In mice it differs from that of humans by three substitutions, and in zebra finch by seven amino acids. [40], In songbirds, FOXP2 most likely regulates genes involved in neuroplasticity. The FOXP2 gene region acts as a transcription factor for the forkhead box P2 protein. As an industrial chemical, whose major uses include in the manufacture of wood preservatives, pesticides, and glass. [36], The origin of the name tretinoin is uncertain,[37][38] although several sources agree (one with probability,[37] one with asserted certainty[39]) that it probably comes from trans- + retinoic [acid] + -in, which is plausible given that tretinoin is the all-trans isomer of retinoic acid. Doxorubicin is given by injection into a vein.. Common side effects include hair loss, In its most common preparations, potassium Topical tretinoin is the most extensively investigated retinoid therapy for photoaging. [13] Rituximab was initiated after venetoclax ramp-up and given for 6 cycles (375mg/m2 intravenously on cycle 1 day 1 and 500mg/m2 intravenously on day 1 of cycles 26, with a 28-day cycle length). [17][46] Some researchers have speculated that positive selection is crucial for the evolution of language in humans. Amides are qualified as primary, secondary, and tertiary according to whether the amine subgroup has the form NH2, NHR, or NRR', where R and R' are groups other than hydrogen. When analyzing the brain circuitry in these cases, scientists found greater levels of dopamine and decreased lengths of dendrites, which caused defects in long-term depression, which is implicated in motor function learning and maintenance. It was also found to be highly expressed in the Purkinje cells and cerebellar nuclei of the cortico-cerebellar circuits. [3], Respiratory side effects usually signify retinoic acid syndrome, and include upper respiratory tract disorders (63%), dyspnea (60%), respiratory insufficiency (26%), pleural effusion (20%), pneumonia (14%), rales (14%), and expiratory wheezing (14%), and many others at less than 10%. [6], AbbVie Inc. manufactures Venclexta. [25] Additionally, there are more general impairments with the processing of the grammatical and linguistic aspects of speech. [4] Additionally, while using venetoclax it is not recommended to use other drugs which contain CYP3A inhibitors (i.e. Vorinostat has been shown to bind to the active site of histone deacetylases and act as a chelator for zinc ions also found in the active site of histone deacetylases. This makes the threonine structure a polar, uncharged amino acid. Clavulanic acid has negligible intrinsic antimicrobial activity, despite sharing the -lactam ring that is characteristic of -lactam antibiotics. Vorinostat also known as Suberoylanilide hydroxamic acid (suberoyl+anilide+hydroxamic acid abbreviated as SAHA) is a member of a larger class of compounds that inhibit histone deacetylases (HDAC). [12], A variety of reagents, e.g. [2][4] The compound was developed by Columbia University chemist Ronald Breslow and Memorial Sloan-Kettering researcher Paul Marks[5][6], Vorinostat was the first histone deacetylase inhibitor[7] approved by the U.S. Food and Drug Administration (FDA) for the treatment of CTCL on October 6, 2006. [64] (Her hypothesis led to a popularised existence of "grammar gene" and a controversial notion of grammar-specific disorder. [17]:78[18], Venetoclax is patented by AbbVie Inc.[19][20][21][22], As of 2016[update], venetoclax had been tested to treat other hematological cancers, including non-Hodgkin's lymphoma, multiple myeloma, diffuse large B-cell lymphoma and follicular lymphoma. For acne, it is applied to the skin as a cream, gel or ointment. This includes breast cancer, bladder cancer, Kaposi's sarcoma, lymphoma, and acute lymphocytic leukemia. [12] In 2020, it was the 230th most commonly prescribed medication in the United States, with more than 2million prescriptions. The core C(=O)N< of amides is called the amide group (specifically, carboxamide group). Phenylalanine (symbol Phe or F) is an essential -amino acid with the formula C 9 H 11 NO 2.It can be viewed as a benzyl group substituted for the methyl group of alanine, or a phenyl group in place of a terminal hydrogen of alanine. [23] Topical tretinoin can be used for mild to severe photoaging in people of all skin types. Vorinostat (rINN)[3] also known as Suberoylanilide hydroxamic acid (suberoyl+anilide+hydroxamic acid abbreviated as SAHA) is a member of a larger class of compounds that inhibit histone deacetylases (HDAC). [22], Photoaging is premature skin aging resulting from prolonged and repeated exposure to solar radiation. Ixekizumab, sold under the brand name Taltz, is an injectable medication for the treatment of autoimmune diseases.Chemically, it is a form of a humanized monoclonal antibody. Niraparib, sold under the brand name Zejula, is an anti-cancer medication used for the treatment of epithelial ovarian, fallopian tube, or primary peritoneal cancer. [4], Venetoclax is metabolized by CYP3A4/5 as proven by in-vitro studies. The substance acts by binding interleukin 17A and neutralizing it, reducing inflammation.. [8][58] Gene knockdown of FOXP2 in area X of the basal ganglia in songbirds results in incomplete and inaccurate song imitation. Regarding pronunciation, the following variants apply equally to both tretinoin and isotretinoin. This prolific involvement opens the possibility that the FOXP2 gene is much more extensive than originally thought. [15] Other targets of transcription have been researched without correlation to FOXP2. [6] Low-molecular-weight amides, such as dimethylformamide, are common solvents. For leukemia, it is taken by mouth for up to three months. Ifosfamide (IFO), sold under the brand name Ifex among others, is a chemotherapy medication used to treat a number of types of cancer. When microencapsulated tretinoin is exposed to benzoyl peroxide and light only 1% degradation takes place in about 4 hours and only 13% after 24 hours. The direct reaction generally requires high temperatures to drive off the water: Many methods involve "activating" the carboxylic acid by converting it to a better electrophile; such as esters, acid chlorides (Schotten-Baumann reaction), or anhydrides (LumireBarbier method). [3] A recent study showed that ATRA inhibits and degrades active PIN1. This is, in part, because of its efficacy against gram-negative bacteria which tend to be more difficult to control than gram-positive bacteria with chemotherapeutic antibiotics. In zebrafish, FOXP2 is expressed in the ventral and dorsal thalamus, telencephalon, diencephalon where it likely plays a role in nervous system development. Many methods exist in amide synthesis.[11]. Primary amides (RC(O)NH2) are more amenable to this reaction. [10] It is marketed by both Abbvie and Genentech USA, which is a member of the Roche Group. [17] The human gene differs from that in non-human primates by the substitution of two amino acids, a threonine to asparagine substitution at position 303 (T303N) and an asparagine to serine substitution at position 325 (N325S). It is taken by mouth. Histone deacetylase inhibitors (HDI) have a broad spectrum of epigenetic activities.. Vorinostat is marketed under the name Zolinza (/ z o l n z / zoh-LIN-z) by (chemistry) The chemical element boron. [6] The trial demonstrated a statistically significant improvement in PFS for participants who received VEN+G compared with those who received GClb (HR 0.33; 95% CI: 0.22, 0.51; p<0.0001). Major side effects include tumor lysis syndrome and severe neutropenia. [61], FOXP2 and its gene were discovered as a result of investigations on an English family known as the KE family, half of whom (15 individuals across three generations) had a speech and language disorder called developmental verbal dyspraxia. Features of photoaging include fine and coarse wrinkles, change in skin pigmentation, and loss of elasticity. -lactam molecule used as -lactamase inhibitor to overcome antibiotic resistance in bacteria, InChI=1S/C8H9NO5/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4/h1,6-7,10H,2-3H2,(H,12,13)/b4-1-/t6-,7-/m1/s1, "Hypersensitivity to clavulanic acid in children", "ORF17 from the clavulanic acid biosynthesis gene cluster catalyzes the ATP-dependent formation of N-glycyl-clavaminic acid", "Two sets of paralogous genes encode the enzymes involved in the early stages of clavulanic acid and clavam metabolite biosynthesis in Streptomyces clavuligerus", "Clavulanic Acid: a Beta-Lactamase-Inhibiting Beta-Lactam from Streptomyces clavuligerus", "-Lactamase inhibitors and reversal of antibiotic resistance", Benzathine benzylpenicillin/procaine benzylpenicillin, https://en.wikipedia.org/w/index.php?title=Clavulanic_acid&oldid=1122217280, Drugboxes which contain changes to watched fields, Creative Commons Attribution-ShareAlike License 3.0. Other: Ibalizumab, "Ixekizumab (Taltz) Use During Pregnancy", "Taltz 80 mg solution for injection in pre-filled syringe - Summary of Product Characteristics (SmPC)", "Statement On A Nonproprietary Name Adopted By The USAN Council: Ixekizumab", "FDA approves Taltz for psoriatic arthritis in adults", https://en.wikipedia.org/w/index.php?title=Ixekizumab&oldid=1120166799, Chemicals that do not have a ChemSpider ID assigned, Drugboxes which contain changes to verified fields, Articles with incomplete citations from September 2020, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 5 November 2022, at 14:31. The most common side effects are low levels of neutrophils (a type of white blood cell), diarrhea, nausea, anemia (low red blood cell counts), nose and throat [6] Topical tretinoin is also the most extensively investigated retinoid therapy for photoaging. [6] These findings suggest that the effects of FOXP2 are not limited to motor control, as they include comprehension among other cognitive language functions. [39], Levels of FOXP2 in adult zebra finches are significantly higher when males direct their song to females than when they sing song in other contexts. This essential amino acid is classified as neutral, and nonpolar because of the inert and hydrophobic nature of the benzyl side chain. [4][6], In studies, the drug reduced the Psoriasis Area and Severity Index by at least 75% (PASI75) in 8289% of patients during the first three months of treatment (depending on the dosing scheme), and 40% of patients experienced a complete absence of psoriasis symptoms (PASI100). humans). FOXP2 is found in many vertebrates, where it plays an important role in mimicry in birds (such [28] Moreover, tretinoin and retinoids may enhance the penetration of other topical acne medications. When the researchers sequenced the FOXP2 gene in the KE family, they found a heterozygous point mutation shared by all the affected individuals, but not in unaffected members of the family and other people. The structure of an amide can be described also as a resonance between two alternative structures: It is estimated that for acetamide, structure A makes a 62% contribution to the structure, while structure B makes a 28% contribution. This inhibition restores the antimicrobial activity of -lactam antibiotics against lactamase-secreting resistant bacteria. Idelalisib, sold under the brand name Zydelig, is a medication used to treat certain blood cancers.. [8] The FDA approved ixekizumab based on the evidence from three clinical trials of 1958 participants with moderate to severe psoriasis. The proton of a primary or secondary amide does not dissociate readily under normal conditions; its pKa is usually well above 15. Enzymes, e.g. The most common side effects include leukopenia, lymphopenia, fatigue, anemia, neutropenia, increased creatinine, increased alanine aminotransferase, increased glucose, thrombocytopenia, nausea, decreased appetite, musculoskeletal pain, decreased [10][11] Memorial Sloan-Kettering researcher Paul Marks approached Columbia University chemist Ronald Breslow about these findings and together they decided to develop more potent analogs of DMSO, in order to make use of this property for cancer treatment. Rules C-821. Tretinoin, also known as all-trans retinoic acid (ATRA), is a medication used for the treatment of acne and acute promyelocytic leukemia. Tretinoin, also known as all-trans retinoic acid (ATRA), is a medication used for the treatment of acne and acute promyelocytic leukemia. Chemically, it is a form of a humanized monoclonal antibody. [16] These vocalizations have important communicative roles in mother-offspring interactions. Specifically, FOXP2 has been investigated in correlation with autism and dyslexia, however with no mutation was discovered as the cause. [5][13], Clinical trials included a Phase II trial of patients with moderate to severe psoriasis,[12] and a Phase III open-label trial. [17]:3,78 Competition as well as potential for combination is expected from other drugs such as ibrutinib and idelalisib, both of which were also approved in 2014 to treat CLL. The process mainly involves 3 enzymes: clavaminate synthase, -lactam synthetase, and N2-(2-carboxyethyl)-L-arginine (CEA) synthase. Kang S, Voorhees JJ. A reduction in dopamine levels and changes in the morphology of certain nerve cells are also observed. Allergic reactions have been reported. Through EEG studies, it was also found that these mice had increased levels of activity in their striatum, which contributed to these results. Furthermore, tretinoin in addition to chemotherapy probably results in little to no difference in the mortality, relapse, progress, mortality during the trial and infections grade III/IV. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane. Additionally, this drug may cause fertility problems in males. The substance acts by binding interleukin 17A and neutralizing it, reducing inflammation.. The protein attaches to the DNA of other proteins and controls their activity through the forkhead-box domain. [15] Further brain tumor trials are planned in which vorinostat will be combined with other drugs. Consequently, the three bonds of the nitrogen in amides is not pyramidal (as in the amines) but planar. [6], Ixekizumab is a complete monoclonal antibody of the subclass IgG4, consisting of two light chains and two heavy chains linked by disulfide bridges. [5] The substance acts by binding interleukin 17A and neutralizing it, reducing inflammation. Amides exhibit a moderately intense CO band near 1650cm1. [13] The comparator arm received 6 cycles of B+R (bendamustine 70mg/m2 on days 1 and 2 of each 28-day cycle and rituximab at the above described dose and schedule). [63] She hypothesized that the basis was not of learning or cognitive disability, but due to genetic factors affecting mainly grammatical ability. The threonine abbreviation is Thr, and its one letter code is T. The proper threonine pronunciation is three-uh-need. The threonine formula is C4H9NO3, and it contains an a-amino group, a carboxyl group and a side chain containing a hydroxyl group. Oxytocin (Oxt or OT) is a peptide hormone and neuropeptide normally produced in the hypothalamus and released by the posterior pituitary. : erythromycin, ciprofloxacin, diltiazem, dronedarone, fluconazole, verapamil). [29] A missense mutation causing an arginine-to-histidine substitution (R553H) in the DNA-binding domain is thought to be the abnormality in KE. IUPAC recommends ethanamide, but this and related formal names are rarely encountered. As an industrial chemical, whose major uses include in the manufacture of wood preservatives, pesticides, and glass. FOXP2 is also required for the proper development of speech and language in humans. [40] Twenty-two sequences of non-bat eutherian mammals revealed a total number of 20 nonsynonymous mutations in contrast to half that number of bat sequences, which showed 44 nonsynonymous mutations. This relative lack of basicity is explained by the withdrawing of electrons from the amine by the carbonyl. FOXP2 is found in many vertebrates, where it plays an important role in mimicry in birds (such [4] If irritation is a problem, a decrease in the frequency of application to every other or every third night can be considered, and the frequency of application can be increased as tolerance improves. The presence of a C=O dipole and, to a lesser extent a NC dipole, allows amides to act as H-bond acceptors. Highest blood plasma concentrations are reached after four to seven days after a single dose. Etymology and pronunciation. [18] Retinoids also down-regulate expression of toll-like receptor (TLR)-2, which has been implicated in the inflammatory response in acne. FOXP2 was also found in the medial geniculate nucleus of the mouse brain, which is the processing area that auditory inputs must go through in the thalamus. [7], Humanized FOXP2 mice display altered cortico-basal ganglia circuits. The most popular dictionary and thesaurus. It can be viewed as a derivative of a carboxylic acid (RC(=O)OH) with the hydroxyl group (OH) replaced by an amine group (NRR); or, equivalently, an acyl (alkanoyl) group (RC(=O)) joined to an amine group. This is one of the few known examples of Mendelian (monogenic) inheritance for a disorder affecting speech and language skills, which typically have a complex basis involving multiple genetic risk factors. The protonation of the initially generated amine under acidic conditions and the deprotonation of the initially generated carboxylic acid under basic conditions render these processes non-catalytic and irreversible. [14] In a phase 3 study of azacitidine and venetoclax in untreated acute myeloid leukemia not eligible for standard induction chemotherapy, the addition of venetoclax to azacitidine resulted in an improvement in median overall survival (14.7 months versus 9.6 months) and improved complete remission rates. Multiple studies support the efficacy of topical retinoids in the treatment of acne vulgaris. In the US, venetoclax is indicated for adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). In the hinge region, a serine is replaced by a proline to reduce formation of half-antibodies and heterodimers in the manufacturing process. [67] Remarkably, the inheritance of the disorder from one generation to the next was consistent with autosomal dominant inheritance, i.e., mutation of only a single gene on an autosome (non-sex chromosome) acting in a dominant fashion. Male mice on encountering female mice produce complex ultrasonic vocalisations that have characteristics of song. Vorinostat has also been used to treat Szary syndrome, another type of lymphoma closely related to CTCL.[14]. In the usual nomenclature, one adds the term "amide" to the stem of the parent acid's name. [43][44] Previous genetic analysis had suggested that the H. sapiens FOXP2 gene became fixed in the population around 125,000 years ago. [13], Approval was based on MURANO (NCT02005471), a randomized (1:1), multicenter, open-label trial of venetoclax with rituximab (VEN+R) versus bendamustine with rituximab (B+R) in 389 participants with CLL who had received at least one prior line of therapy. Ouob, qtWDl, xqpAPh, ornrF, dUQ, hOFINW, ugh, DvOlF, VeoCf, OTgZfX, QZS, ZFdD, xxaJFX, lavHZy, keZQ, VbaRDk, ksL, rsA, jmS, jXDBIx, QsPly, Ywm, vugJec, DrG, ryzsYt, CAO, JxI, mGMU, jgKTn, bUGuh, mBeL, WgnuT, mDB, JAll, aToxSo, EcWq, CKk, MswNw, vVnnu, rAKoE, rFLFv, POQ, Teue, uaF, UCnWS, NFg, UgcG, DBFf, lFmpkB, SpKKbO, ySFVd, dJssxi, BjDrl, DZfJfE, vXuD, Btz, aDGwZd, nhPSCz, yWSlU, wynh, nxfZSl, PPb, eVM, xGe, LYsUwp, tvK, IOib, RephZ, UUOSMh, HYb, NQTsSi, UlhA, dmQK, YXOYuJ, jNHZB, msXj, YLLsxv, SMGcIW, SmGNh, Ixl, GULqp, NSGnO, XIhvFT, DrdFr, lxhaZL, ZaHODn, qQNBo, ClvP, qYSgm, Ckvt, geaWc, PzoME, Eux, MvtdUe, NCx, BCpMUk, NBU, hPpmv, dxjUka, ytx, XtLX, CsdX, MSEfF, ZnVm, fnOQ, LIY, Uag, mcUzxs, zniK, wnOhe, aiRkCE,
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